The cerebral metabolic rate of oxygen (CMRO2) is an interesting biomarker and can be used as a diagnostic parameter in various neurodegenerative diseases or tumors. A dynamic 17O MRI inhalation method was optimized for application in a clinical setting and employed in two patient examinations to investigate CMRO2 in human brain tumors as part of an ongoing pilot study. In tumor tissue, a decrease in oxygen consumption was detected, which is in consistent with the Warburg effect. To our knowledge, the presented work includes the first patient study with dynamic 17O MRI.
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