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Abstract #0625

Metabolic Rate of Oxygen Consumption in Brain Tumors: A Pilot 17O-MRI Study

Sebastian C. Niesporek1, Armin M. Nagel1,2, Reiner Umathum1, Nicolas G.R. Behl1, Mark E. Ladd1, Heinz-Peter Schlemmer3, and Daniel Paech3

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 3Division of Radiology, German Cancer Research Center (DKFZ), Heidelverg, Germany

The cerebral metabolic rate of oxygen (CMRO2) is an interesting biomarker and can be used as a diagnostic parameter in various neurodegenerative diseases or tumors. A dynamic 17O MRI inhalation method was optimized for application in a clinical setting and employed in two patient examinations to investigate CMRO2 in human brain tumors as part of an ongoing pilot study. In tumor tissue, a decrease in oxygen consumption was detected, which is in consistent with the Warburg effect. To our knowledge, the presented work includes the first patient study with dynamic 17O MRI.

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