Meeting Banner
Abstract #0626

In vivo investigation of lithium brain distribution in bipolar patients using 7Li MRI

Jacques Andrew Stout1, Arthur Coste1, Franz Hozer1,2,3, Franck Mauconduit4, Sandro Romanzetti5, Edouard Duchesnay1, Cécile Lerman1, Josselin Houenou1,2,3, Frank Bellivier2,3,6, and Fawzi Boumezbeur1

1NeuroSpin, CEA, Gif-sur-Yvette, France, 2Hôpital Fernand Widal, Paris, France, 3Hôpital Albert Chenevrier, Créteil, France, 4Siemens Healthineers, Saint-Denis, France, 5Neurology, RWTH Aachen University Hospital, Aachen, Germany, 6INSERM UMRS-1144, Paris, France

As an effective but poorly understood treatment for the prevalent bipolar disorder, studies focused on investigating the cerebral distribution of lithium are of important clinical interest. Here, we report our preliminary results obtained from 5 euthymic bipolar patients using 7Li MRI at 7T. Using a 3D SSFP sequence with ultra-short TE and Twisted Projection Imaging k-space sampling, we can confirm the heterogeneity of lithium brain distribution, as demonstrated by the individual and average concentration values in seven large regions-of-interest.

This abstract and the presentation materials are available to members only; a login is required.

Join Here