Abstract #0626

In vivo investigation of lithium brain distribution in bipolar patients using 7Li MRI

Jacques Andrew Stout¹, Arthur Coste¹, Franz Hozer^1,2,3, Franck Mauconduit⁴, Sandro Romanzetti⁵, Edouard Duchesnay¹, Cécile Lerman¹, Josselin Houenou^1,2,3, Frank Bellivier^2,3,6, and Fawzi Boumezbeur¹

¹NeuroSpin, CEA, Gif-sur-Yvette, France, ²Hôpital Fernand Widal, Paris, France, ³Hôpital Albert Chenevrier, Créteil, France, ⁴Siemens Healthineers, Saint-Denis, France, ⁵Neurology, RWTH Aachen University Hospital, Aachen, Germany, ⁶INSERM UMRS-1144, Paris, France

As an effective but poorly understood treatment for the prevalent bipolar disorder, studies focused on investigating the cerebral distribution of lithium are of important clinical interest. Here, we report our preliminary results obtained from 5 euthymic bipolar patients using ⁷Li MRI at 7T. Using a 3D SSFP sequence with ultra-short TE and Twisted Projection Imaging k-space sampling, we can confirm the heterogeneity of lithium brain distribution, as demonstrated by the individual and average concentration values in seven large regions-of-interest.

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