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Abstract #0629

Collagen is a major determinant of the viscoelastic properties of stromal-dense tumours: insights from pre-clinical MRE

Jin Li1, Konstantinos Zormpas-Petridis1, Andreas Heindl2, Jessica K.R. Boult1, Craig Cummings1, Jeffrey C. Bamber1, Yinyin Yuan2, Ralph Sinkus3, Yann Jamin1, and Simon P. Robinson1

1Division of Radiotherapy & Imaging, The Institute of Cancer Research, London, United Kingdom, 2Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom, 3Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, United Kingdom

The relationship of magnetic resonance elastography-derived viscoelasticity quantified in vivo in nine pre-clinical tumour models exhibiting varying degrees of stromal density was compared with histological assessments of cellularity, collagen and vessel density. Both cellularity and collagen deposition were identified as important determinants of the relative tumour stiffness.

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