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Abstract #0630

Pre-existing inflammation in the brain promotes metastases invasion

Dina Sikpa1, Lisa Whittingstall1, Jérémie P. Fouquet1, Luc Tremblay1, Réjean Lebel1, and Martin Lepage1

1Université de Sherbrooke, Sherbrooke, QC, Canada

We studied the effect of pre-existing inflammation on the genesis of brain metastases using MRI. Molecular MRI enhanced with VCAM-1 targeted microparticles of iron oxide enable the assessment of pre-existing vascular inflammation and then of metastasis implantation. The occurrence of brain metastases was increased by 2 fold when inflammation was present; this could be blocked with VCAM-1 antibody. This underlies the key role of VCAM-1 in tumor seeding to the brain, and suggests that preventive inflammation targeted treatment in cancer patients may minimize risks of brain metastasis.

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