Meeting Banner
Abstract #0631

Imaging the Interplay of Tumor Vascularity, Hypoxia, pHe, and Lactate

Ellen Ackerstaff1, Natalia Kruchevsky1, Ekaterina Moroz1, H. Carl LeKaye1, Kristen L. Zakian1, SoHyun Han2, HyungJoon Cho2, Radka Stoyanova3, Nirilanto Ramamonjisoa1, Inna S. Serganova1, Vladimir Ponomarev1, Ronald G. Blasberg1, and Jason A. Koutcher1

1Memorial Sloan Kettering Cancer Center, New York, NY, United States, 2Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea, 3Sylverster Comprehensive Cancer Center, Miller School of Medicine University of Miami, Miami, FL, United States

We characterized tumor vascularity, extracellular pH (pHe), and tumor lactate in various tumor models, focusing on prostate cancer. Spatial mapping demonstrated that vascular blood flow and permeability varied significantly in well-vascularized regions across tumor models and that the fraction of tumor necrosis was higher in the human than the murine models. The spatially most heterogeneous tumor type was characterized by the lowest lactate, a pHe of ~7.1 in well-vascularized regions, with lower pHe in less vascularized regions, and increasing lactate with decreasing vascular blood flow and permeability.

This abstract and the presentation materials are available to members only; a login is required.

Join Here