Abstract #0661

Real-time motion and dynamic transmit/receive B1 correction of CEST in the human brain at 7T

Sami Auno^1,2, Esau Poblador Rodriguez^1,3, Philipp Moser^1,3, Andre v.d.Kouwe⁴, Stephan Gruber¹, Siegfried Trattnig^1,3, and Wolfgang Bogner¹

¹High-Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Department of Physics, University of Helsinki, Helsinki, Finland, ³Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, ⁴Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States

Movement during MR imaging may cause significant motion artifacts that can impair the experiment. This is especially true in CEST imaging, which relies on comparison between images recorded at different time points during the experiment. We implemented a real-time motion correction method and a retrospective receiver sensitivity(B₁^-) correction based on volumetric EPI navigators interleaved with the CEST measurements. We tested these methods on phantoms and healthy volunteers. Together with adequate B₀ and B₁⁺ corrections, motion and sensitivity corrections may completely restore CEST data fidelity in the presence of involuntary head motion, thereby facilitating CEST imaging of restless patients.

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