Abstract #0668

In vivo visualization of white and gray matter sub-structures using fast quantitative T1 mapping of the human spinal cord at 7T with 300-µm in-plane resolution

Aurélien Massire^1,2,3, Henitsoa Rasoanandrianina^1,2,3, Manuel Taso^1,2,3,4, Arnaud Le Troter^1,3, Maxime Guye^1,3, Jean-Philippe Ranjeva^1,2,3, and Virginie Callot^1,2,3

¹Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, ²iLab-Spine - Laboratoire international - Imagerie et Biomécanique du rachis, Marseille, France, ³APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, ⁴Division of MRI Research, Department of Radiology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States

T₁ mapping of the cervical spinal cord at 7T with a 300-µm in-plane resolution using the MP2RAGE sequence is presented. A semi-automated post-processing pipeline enabled group studies (n=10 healthy subjects) with quantitative evaluation within small spinal cord sub-structures from C1 to C7, explored for the first time using T₁ mapping. This work lays the groundwork for improved characterization of spinal cord degeneration using 7T MRI, by allowing investigation within particular relevant regions such as the anterior/posterior gray matter horns and ventromedial white matter tracts. It also offers new perspectives to build dedicated spinal cord substructures templates.

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