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Abstract #0668

In vivo visualization of white and gray matter sub-structures using fast quantitative T1 mapping of the human spinal cord at 7T with 300-µm in-plane resolution

Aurélien Massire1,2,3, Henitsoa Rasoanandrianina1,2,3, Manuel Taso1,2,3,4, Arnaud Le Troter1,3, Maxime Guye1,3, Jean-Philippe Ranjeva1,2,3, and Virginie Callot1,2,3

1Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2iLab-Spine - Laboratoire international - Imagerie et Biomécanique du rachis, Marseille, France, 3APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 4Division of MRI Research, Department of Radiology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA, United States

T1 mapping of the cervical spinal cord at 7T with a 300-µm in-plane resolution using the MP2RAGE sequence is presented. A semi-automated post-processing pipeline enabled group studies (n=10 healthy subjects) with quantitative evaluation within small spinal cord sub-structures from C1 to C7, explored for the first time using T1 mapping. This work lays the groundwork for improved characterization of spinal cord degeneration using 7T MRI, by allowing investigation within particular relevant regions such as the anterior/posterior gray matter horns and ventromedial white matter tracts. It also offers new perspectives to build dedicated spinal cord substructures templates.

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