Abstract #0669

Spinal cord MRI and fMRI at 16.4 T during spinal cord stimulation in rats: initial experience

Hanne Laakso^1,2, Lauri J Lehto¹, Carlos Cuellar³, Igor Lavrov³, John Osborn⁴, Shalom Michaeli¹, and Silvia Mangia¹

¹Center for Magnetic Resonance in Research, University of Minnesota, Minneapolis, MN, United States, ²A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ³Neural Engineering Laboratory, Mayo Clinic, Rochester, MN, United States, ⁴Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, United States

This study aims at paving the way for spinal cord MRI and fMRI during spinal cord stimulation (SCS) in rats, with the goal of providing an experimental framework for assessing the impact of SCS on neuroplasticity and functional circuitry. MRI and fMRI of the spinal cord during SCS are extremely challenging due to motion and electrode-induced susceptibility artefacts. Here we demonstrated that high quality MRI and fMRI images of the spinal cord could be obtained at 16.4T during SCS with recently developed MB-SWIFT. This is the first study that attempts spinal cord fMRI during SCS in rats.

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