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Abstract #0669

Spinal cord MRI and fMRI at 16.4 T during spinal cord stimulation in rats: initial experience

Hanne Laakso1,2, Lauri J Lehto1, Carlos Cuellar3, Igor Lavrov3, John Osborn4, Shalom Michaeli1, and Silvia Mangia1

1Center for Magnetic Resonance in Research, University of Minnesota, Minneapolis, MN, United States, 2A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, 3Neural Engineering Laboratory, Mayo Clinic, Rochester, MN, United States, 4Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN, United States

This study aims at paving the way for spinal cord MRI and fMRI during spinal cord stimulation (SCS) in rats, with the goal of providing an experimental framework for assessing the impact of SCS on neuroplasticity and functional circuitry. MRI and fMRI of the spinal cord during SCS are extremely challenging due to motion and electrode-induced susceptibility artefacts. Here we demonstrated that high quality MRI and fMRI images of the spinal cord could be obtained at 16.4T during SCS with recently developed MB-SWIFT. This is the first study that attempts spinal cord fMRI during SCS in rats.

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