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Abstract #0677

MR Fingerprinting for High Resolution Metabolic Imaging of Hyperpolarized [1-13C]Pyruvate

Cornelius von Morze1, Eugene Milshteyn1, Peder E. Larson1, Galen D. Reed2, John M. Pauly3, Duan Xu1, and Daniel B. Vigneron1

1Department of Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States, 2GE Healthcare, San Francisco, CA, United States, 3Department of Electrical Engineering, Stanford University, Stanford, CA, United States

The purpose of this study was to investigate a new application of MR fingerprinting (MRF) methods for hyperpolarized 13C MRI. We show that introducing randomization of pulse parameters into a 13C SSFP acquisition train facilitates efficient extraction of individual hyperpolarized 13C metabolite levels based on their transient signal responses (i.e. "fingerprints"), in simulations as well as phantom and in vivo experiments. Application of MRF methods in this multi-spectral SSFP framework enables exploitation of the long T2 relaxation times of 13C nuclei for increased sensitivity and spatial resolution in hyperpolarized MRI. Initial results show that MRF approaches have great potential for application to hyperpolarized 13C metabolic imaging.

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