Abstract #0677

MR Fingerprinting for High Resolution Metabolic Imaging of Hyperpolarized [1-13C]Pyruvate

Cornelius von Morze¹, Eugene Milshteyn¹, Peder E. Larson¹, Galen D. Reed², John M. Pauly³, Duan Xu¹, and Daniel B. Vigneron¹

¹Department of Radiology & Biomedical Imaging, UCSF, San Francisco, CA, United States, ²GE Healthcare, San Francisco, CA, United States, ³Department of Electrical Engineering, Stanford University, Stanford, CA, United States

The purpose of this study was to investigate a new application of MR fingerprinting (MRF) methods for hyperpolarized ¹³C MRI. We show that introducing randomization of pulse parameters into a ¹³C SSFP acquisition train facilitates efficient extraction of individual hyperpolarized ¹³C metabolite levels based on their transient signal responses (i.e. "fingerprints"), in simulations as well as phantom and in vivo experiments. Application of MRF methods in this multi-spectral SSFP framework enables exploitation of the long T₂ relaxation times of ¹³C nuclei for increased sensitivity and spatial resolution in hyperpolarized MRI. Initial results show that MRF approaches have great potential for application to hyperpolarized ¹³C metabolic imaging.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.