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Abstract #0678

MR Vascular Fingerprinting during Gas Challenges

Thomas Christen1, Wendi W. Ni1, Jia Guo1, Audrey P. Fan1, Michael M. Moseley1, and Greg Zaharchuk1

1Radiology, Stanford University, Stanford, CA, United States

The MR vascular fingerprinting (MRvF) approach extends the concept of MR fingerprinting to the study of microvascular properties and functions. Encouraging results have been obtained in healthy human volunteers as well as in stroke and tumor models in rats. However, it has been suggested that the method has a low sensitivity to blood oxygenation measurements. In this study, we tested the MRvF approach in healthy volunteers while breathing different gas mixtures (Hyperoxia (100%O2), Normoxia (21%O2), hypoxia (14%O2)) and examined the results when different types of fingerprints are considered.

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