Abstract #0679

Correlation of MR fingerprinting with whole mount histopathology reveals epithelial and stromal density drive T1, T2 measurements in regions of prostatitis and prostate cancer: Preliminary findings

Rakesh Shiradkar¹, Ananya Panda², Shivani Pahwa³, Lin Li¹, Patrick Leo¹, Nafiseh Janaki⁴, Lee Ponsky⁵, Robin Elliott⁴, Vikas Gulani^2,3, and Anant Madabhushi¹

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Radiology, Case Western Reserve University, Cleveland, OH, United States, ³Radiology, University Hospitals, Cleveland, OH, United States, ⁴Pathology, University Hospitals, Cleveland, OH, United States, ⁵Urology, University Hospitals, Cleveland, OH, United States

Magnetic Resonance Fingerprinting (MRF) is a new technology aimed at generating quantitative T1 and T2 maps. In this study, histo-morphometric attributes that may be driving the MRF measurements of cancerous and prostatitis regions are explored via correlation of in vivo MRF maps with post surgical ex vivo histopathology. Our results suggest that epithelial density may be driving T1 and T2 MRF measurements in prostatitis regions while stromal density may be driving the T1 MRF signals within cancerous regions.

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