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Abstract #0703

A Novel Method for Direct Detection and Spatial Mapping of Neuronal Activity

Jeongtaek Lee1, Seung-Kyun Lee1,2, and Jang-Yeon Park1,2

1Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea, 2Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Republic of Korea

Although BOLD-fMRI is widely used for in-vivo functional brain mapping, there has been continuing interest in the possibility of using MRI to directly detect the neuronal activity. However, previous works failed to reach a clear consensus on that possibility. Here, we proposed a novel method for direct detection and spatial mapping of neuronal activity with temporal resolution on the order of the action-potential duration(4~5ms). We demonstrated its feasibility using an ex-vivo squid axon and an insulated copper-wire in an event-related electrical-stimulation paradigm. The results are very exciting and promising, although the underlying contrast mechanism needs to be elucidated.

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