Although BOLD-fMRI is widely used for in-vivo functional brain mapping, there has been continuing interest in the possibility of using MRI to directly detect the neuronal activity. However, previous works failed to reach a clear consensus on that possibility. Here, we proposed a novel method for direct detection and spatial mapping of neuronal activity with temporal resolution on the order of the action-potential duration(4~5ms). We demonstrated its feasibility using an ex-vivo squid axon and an insulated copper-wire in an event-related electrical-stimulation paradigm. The results are very exciting and promising, although the underlying contrast mechanism needs to be elucidated.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords