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Abstract #0704

Mapping Neural Circuitry at High Speed (10Hz) using functional Magnetic Resonance Elastography (fMRE)

Samuel Patz1,2, Daniel Fovargue3, Katharina Schregel1,2,4, Navid Nazari5, Miklos Palotai1,2, Paul E. Barbone6, Ben Fabry7, Alexander Hammers3, Sverre Holm8, Sebastian Kozerke9, David Nordsletten3, and Ralph Sinkus3

1Radiology, Brigham & Women's Hospital, Boston, MA, United States, 2Radiology, Harvard Medical School, Boston, MA, United States, 3Imaging Sciences and Biomedical Engineering, Kings College London, London, United Kingdom, 4Neuroradiology, University Medical Center Goettingen, Goettingen, Germany, 5Biomedical Engineering, Boston University, Boston, MA, United States, 6Mechanical Engineering, Boston University, Boston, MA, United States, 7Physics, University of Erlangen, Erlangen, Germany, 8Informatics, University of Oslo, Oslo, Norway, 9Biomedical Engineering, ETH, Zurich, Switzerland

Using MR elastography, the shear modulus of a mouse brain was monitored during noxious stimulation. Localized changes in tissue elasticity of >10% were observed in previously identified regions associated with noxious stimuli. The observed mechanical response persists over two decades of stimulus frequencies from 0.1-10 Hz. This demonstrates the mechanism behind the change in stiffness is not of vascular origin, which has a much slower response than 10Hz. but rather is either directly related to, or tightly coupled to primary neuronal activity. This opens a new window to explore the spatio-temporal processing of signals in the brain.

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