Abstract #0704

Mapping Neural Circuitry at High Speed (10Hz) using functional Magnetic Resonance Elastography (fMRE)

Samuel Patz^1,2, Daniel Fovargue³, Katharina Schregel^1,2,4, Navid Nazari⁵, Miklos Palotai^1,2, Paul E. Barbone⁶, Ben Fabry⁷, Alexander Hammers³, Sverre Holm⁸, Sebastian Kozerke⁹, David Nordsletten³, and Ralph Sinkus³

¹Radiology, Brigham & Women's Hospital, Boston, MA, United States, ²Radiology, Harvard Medical School, Boston, MA, United States, ³Imaging Sciences and Biomedical Engineering, Kings College London, London, United Kingdom, ⁴Neuroradiology, University Medical Center Goettingen, Goettingen, Germany, ⁵Biomedical Engineering, Boston University, Boston, MA, United States, ⁶Mechanical Engineering, Boston University, Boston, MA, United States, ⁷Physics, University of Erlangen, Erlangen, Germany, ⁸Informatics, University of Oslo, Oslo, Norway, ⁹Biomedical Engineering, ETH, Zurich, Switzerland

Using MR elastography, the shear modulus of a mouse brain was monitored during noxious stimulation. Localized changes in tissue elasticity of >10% were observed in previously identified regions associated with noxious stimuli. The observed mechanical response persists over two decades of stimulus frequencies from 0.1-10 Hz. This demonstrates the mechanism behind the change in stiffness is not of vascular origin, which has a much slower response than 10Hz. but rather is either directly related to, or tightly coupled to primary neuronal activity. This opens a new window to explore the spatio-temporal processing of signals in the brain.

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