Abstract #0705

Hypercapnia-induced vasodilatation increases brain stiffness

Stefan Hetzer^1,2, Karl Bormann¹, Florian Dittmann³, Philipp Sonnenschein^1,2, Sebastian Hirsch^1,2, Jürgen Braun⁴, and Ingolf Sack³

¹Berlin Center for Advanced Neuroimaging, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Bernstein Center for Computational Neuroscience, Berlin, Germany, ³Institute of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Institute of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany

Cerebral MR elastography paired with arterial spin labelling was applied to a group of healthy male subjects during a hypercapnia challenge to analyze the interrelation between cerebral blood flow and mechanical properties of brain tissue in vivo. Hypercapnia-induced vasodilation and the associated increase in blood perfusion was accompanied by a highly significant increase in global cerebral stiffness by 3% (p<0.0001).

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