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Abstract #0707

Functional sodium (23Na) MRI at 7T -  Extracellular sodium decreases during cortical activation in the Human brain

Jean-Philippe RANJEVA1,2, Mark BYDDER1, Benjamin RIDLEY1, Manon SOUBRIER1, Marie BERTINETTI1, Maxime GUYE1, Lothar SCHAD3, and Wafaa ZAARAOUI1

1Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2AP-HM, Timone Uinv Hospital, CEMEREM, Marseille, France, 3Computer Assisted Clinical Medicine, Centre for Biomedicine and Medical Technology Mannheim, Heidelberg University, Mannheim, Germany

Using dynamic multiecho 3D 23Na MRI with a temporal resolution of 25s, we demonstrated that functional 23Na MRI at 7T was sensitive enough to observe non-invasively in the Human brain, sodium signal variations during a conventional hand motor task. This acquisition performed at 3 different TEs showed that the closest spatial pattern of sodium signal changes relative to BOLD activation was the decrease of 23Na signal at long TE (19ms) assuming to mostly reflect the extracellular sodium changes. This work opens a new ear to better understand normal and abnormal activity-dependent metabolic coupling in the neuro-glia-vasculature ensemble.

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