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Abstract #0708

BOLD fMRI with 0.5 mm isotropic voxel size and minimal in-plane distortion using 3D planes-on-a-paddlewheel (POP) EPI at 7 Tesla

Saskia Bollmann1, Daniel Staeb1, and Markus Barth1

1Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia

High spatial resolution is essential for blood oxygenation level dependent fMRI of laminar or columnar structures and a voxel size of 0.5 mm would be desirable. With common 2D EPI acquisitions this leads to prohibitively long readout trains, echo times and high in-plane distortions. We therefore propose a 3D POP EPI with minimal in-plane distortion and an echo time dependent on the number of slices that can achieve 0.5 mm isotropic resolution. We further investigate analysis methods based on classical and Bayesian statistical inference for this high-resolution data and show the gained sensitivity when using the Bayesian inference scheme.

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