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Abstract #0722

Diffusion MRI Detects and Differentiates Inflammation from Cancer Cells in Prostate Cancer Patients

Zezhong Ye1, Qingsong Yang2, Joshua Lin1, Jeff Viox1, Peng Sun1, Joesph Ippolito 1, Jianping Lu2, and Sheng-Kwei Song1

1Radiology, Washington University School of Medicine, St. Louis, MO, United States, 2Radiology, Changhai Hospital, Shanghai, China

Recent consensus suggested PCa detection based on mpMRI lacks necessary sensitivity or specificity to differentiate prostatitis from PCa, which results in over-diagnosis and over-treatment. Our novel method, diffusion MRI histology (D-Histo), demonstrated its ability to accurately localize, quantify and distinguish between PCa and prostatitis. D-Histo’s improved diagnosis accuracy could more effectively guide treatment planning and assess treatment efficacy.

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