Abstract #0729

Elevated cerebral blood flow in amyloid-positive elderly cognitively normal controls

Sudipto Dolui^1,2, Zhengjun Li¹, Duygu Tosun³, Michael W. Weiner³, David A. Wolk², and John A. Detre^1,2

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Radiology and Biomedical Imaging, University of California – San Francisco, San Francisco, CA, United States

We evaluated the effects of [18F]-Florbetapir PET-derived amyloid (A$$$\beta$$$) status on regional cerebral blood flow (CBF) measured using pulsed arterial spin labeling (PASL) in control subjects from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. Mean CBF in whole grey matter, posterior cingulate and precuneus showed significantly higher CBF in amyloid positive (A$$$\beta$$$+) group compared to the amyloid negative (A$$$\beta$$$-) group after eliminating subjects with poor PASL data quality as assessed by an automated algorithm. Subjects with higher CBF in the A$$$\beta$$$- group also demonstrated better episodic memory whereas a reverse trend was observed in the A$$$\beta$$$+ group.

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