Abstract #0728

Brain 1H-MRS and volumetric changes predict conversion from Mild Cognitive Impairment to Alzheimer’s disease: a follow-up study

Micaela Mitolo^1,2, Michelangelo Stanzani-Maserati³, Stefania Evangelisti^1,2, Lia Talozzi^1,2, Federico Oppi³, Roberto Poda³, Claudio Bianchini^1,2, Lorenzo Cirignotta^1,2, Luisa Sambati², David Neil Manners^1,2, Claudia Testa^1,2, Sabina Capellari^2,3, Roberto Gallassi³, Rocco Liguori^2,3, Raffaele Lodi^1,2, and Caterina Tonon^1,2

¹Functional MR Unit, Policlinico S.Orsola - Malpighi, Bologna, Italy, ²Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy, ³IRCCS Institute of Neurological Sciences, Bologna, Italy

Predicting the possible evolution from the prodromal MCI stage to dementia is a great challenge for both clinic practice and research. We investigated the predictive role of magnetic resonance spectroscopy and brain volumetry in the progression from Mild Cognitive Impairment (MCI) to Alzheimer’s Disease (AD). The (NAA+NAAG)/ml ratio in the Posterior Cingulate Cortex (PCC) discriminates at baseline MCI converters from non-converters with an accuracy of 79% after a mean follow-up of 28 months. Volumetric reduction of the parahippocampal gyrus and fusiform gyrus was also found to be an accurate marker of progression to AD (Accuracy 84.2% and 73.6% respectively).

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