Meeting Banner
Abstract #0728

Brain 1H-MRS and volumetric changes predict conversion from Mild Cognitive Impairment to Alzheimer’s disease: a follow-up study

Micaela Mitolo1,2, Michelangelo Stanzani-Maserati3, Stefania Evangelisti1,2, Lia Talozzi1,2, Federico Oppi3, Roberto Poda3, Claudio Bianchini1,2, Lorenzo Cirignotta1,2, Luisa Sambati2, David Neil Manners1,2, Claudia Testa1,2, Sabina Capellari2,3, Roberto Gallassi3, Rocco Liguori2,3, Raffaele Lodi1,2, and Caterina Tonon1,2

1Functional MR Unit, Policlinico S.Orsola - Malpighi, Bologna, Italy, 2Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy, 3IRCCS Institute of Neurological Sciences, Bologna, Italy

Predicting the possible evolution from the prodromal MCI stage to dementia is a great challenge for both clinic practice and research. We investigated the predictive role of magnetic resonance spectroscopy and brain volumetry in the progression from Mild Cognitive Impairment (MCI) to Alzheimer’s Disease (AD). The (NAA+NAAG)/ml ratio in the Posterior Cingulate Cortex (PCC) discriminates at baseline MCI converters from non-converters with an accuracy of 79% after a mean follow-up of 28 months. Volumetric reduction of the parahippocampal gyrus and fusiform gyrus was also found to be an accurate marker of progression to AD (Accuracy 84.2% and 73.6% respectively).

This abstract and the presentation materials are available to members only; a login is required.

Join Here