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Abstract #0727

Multinuclear MR and PET for Studying Energetic Adaptations in Individuals at Increased Risk for Alzheimer’s Disease

Prodromos Parasoglou1, Lisa Mosconi2, Oleksandr Khegai1, Margo Miller3, Seena Dehkharghani1, Antonio Convit3, Ricardo S Osorio3, and Ryan Brown1

1Department of Radiology, NYU School of Medicine, New York, NY, United States, 2Department of Neurology, Weill Cornell Medical College, New York, NY, United States, 3Department of Psychiatry, NYU School of Medicine, New York, NY, United States

31P-MRS directly assesses metabolites linked to cellular metabolism, which may be altered at the early stages of Alzheimer’s disease (AD). A major challenge for 31P-MRS is the low sensitivity of the 31P nucleus. Therefore, 31P-MRS has only been used sporadically in AD research. To address this, we built a highly-sensitive dual-nuclei (31P/1H) radio frequency coil array and acquired whole-brain 31P-MRS data from cognitive normal subjects at increased risk for AD, who had previously received FDG and amyloid-PET evaluations. Our goal was to detect energetic abnormalities in this pre-clinical population and compare 31P-MRS findings with established PET-based biomarkers of AD.

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