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Abstract #0726

Non-invasive Assessment of Glymphatic Inflow: Measurement of Perivascular Fluid Movement using Diffusion Tensor MRI

Jack A Wells1, Ian F Harrison 1, Bernard A Siow2, Aisha B Akilo1, Phoebe Evans1, Ozama Ismail1, Yolanda Ohene1, Payam Nahavandi1, David L Thomas3,4, and Mark F Lythgoe1

1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 2Francis Crick Institute, London, United Kingdom, 3Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, University College London, London, United Kingdom, 4Leonard Wolfson Experimental Neurology Centre, UCL Institute of Neurology, University College London, London, United Kingdom

The glymphatic system may play a critical role in the parenchymal clearance of amyloid beta, a leading molecular candidate to initiate Alzheimer’s disease. Clinical investigation, however, is currently hindered by an absence of non-invasive techniques for assessment. The movement of fluid in the perivascular space represents a central component of the glymphatic pathway. Here, we present the first non-invasive evaluation of glymphatic function by using an ultra-long echo-time, low b-value, diffusion-tensor sequence targeted to the perivascular space of the rat brain. We demonstrate that this novel technique is sensitive to the fluid movement along perivascular channels that drives glymphatic inflow.

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