Abstract #0725

Increased BBB leakage to water but not gadolinium in a rat model of Alzheimer’s disease

Ben R Dickie¹, José Ulloa², Hervé Boutin¹, Laura M Parkes¹, and Geoff JM Parker³

¹Division of Neuroscience and Experimental Psychology, The University of Manchester, Manchester, United Kingdom, ²Bioxydyn Ltd, The University of Manchester, Manchester, United Kingdom, ³Bioxydyn Ltd & Division of Informatics, Imaging, and Data Sciences, The University of Manchester, Manchester, United Kingdom

The presence of blood-brain barrier (BBB) dysfunction in patients with Alzheimer’s disease (AD) is unclear. This study uses a novel MRI approach to study AD and age-related alterations in BBB leakage to water (PS_w) and gadolinium (K^trans) in a transgenic rat model of AD. We show PS_w is increased in transgenic animals relative to wild-types but that K^trans is independent of genotype. This study demonstrates the benefit of probing the BBB with molecules of different sizes, and suggests measurements of BBB permeability to water are more sensitive to AD-related BBB alterations than estimates of gadolinium leakage.

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