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Abstract #0724

Imaging disruption of blood-brain-barrier (BBB) in Mild Cognitive Impairment without using contrast agent

Zixuan Lin1, Sandeepa Sur1, Peiying Liu1, Jill De Vis1, Yang Li1, Pan Su1, Jay Pillai1, Sevil Yasar2, Paul Rosenberg3, Marilyn Albert2, Abhay Moghekar2, and Hanzhang Lu1

1Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, 2Department of Neurology, Johns Hopkins University, Baltimore, MD, United States, 3Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, United States

Disruption of BBB in AD has received increasing attention due to its potential role in amyloid accumulation and clearance. However, measurement of BBB leakage in AD has been proven challenging, especially when using non-contrast techniques. In this study, we measured BBB permeability to water in MCI patients using a novel technique that does not require any contrast agent. It was found that MCI patients have a higher permeability-surface-area-product (PS), i.e. leaky BBB, compared to elderly controls. Individuals with higher PS values had poorer cognitive performance and more severe vascular inflammation. These findings support the role of BBB disruption in AD.

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