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Abstract #0735

The existence of the inferior fronto-occipital fasciculus (IFOF) revealed in the non-human primate by ex-vivo diffusion-weighted tractography and blunt dissection.

Laurent Petit1, Silvio Sarubbo2, Alessandro De Benedictis3, Franco Chioffi2, Maurice Ptito4,5, and Tim B Dyrby6,7

1Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives (GIN-IMN) - UMR 5293, CNRS, CEA Université de Bordeaux, Bordeaux, France, 2Division of Neurosurgery, Structural and Functional Connectivity Lab, Azienda Provinciale per i Servizi Sanitari (APSS), Trento, Italy, 3Neurosurgery Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children Hospital, IRCCS, Rome, Italy, 4École d'optometrie, Université de Montréal, Montreal, QC, Canada, 5Laboratory of Neuropsychiatry and Psychiatric Centre Copenhagen, University of Copenhagen, Copenhagen, Denmark, 6Danish Research Centre for Magnetic Resonance, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, 7Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark

The existence of a ventral fronto-occipital association pathway in non-human primates similar to the inferior fronto-occipital fasciculus (IFOF) in humans, is nowadays still largely debated. In this study, we elucidate the existence, course and terminations of such a pathway using in the same non-human primate (vervet monkey) both ex-vivo diffusion-weighted tractography and blunt microdissection. From a methodological point of view, it allows an unprecedented anatomical validation of advanced tractography with microdissection for the first time in the same specimen.

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