Abstract #0735

The existence of the inferior fronto-occipital fasciculus (IFOF) revealed in the non-human primate by ex-vivo diffusion-weighted tractography and blunt dissection.

Laurent Petit¹, Silvio Sarubbo², Alessandro De Benedictis³, Franco Chioffi², Maurice Ptito^4,5, and Tim B Dyrby^6,7

¹Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives (GIN-IMN) - UMR 5293, CNRS, CEA Université de Bordeaux, Bordeaux, France, ²Division of Neurosurgery, Structural and Functional Connectivity Lab, Azienda Provinciale per i Servizi Sanitari (APSS), Trento, Italy, ³Neurosurgery Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children Hospital, IRCCS, Rome, Italy, ⁴École d'optometrie, Université de Montréal, Montreal, QC, Canada, ⁵Laboratory of Neuropsychiatry and Psychiatric Centre Copenhagen, University of Copenhagen, Copenhagen, Denmark, ⁶Danish Research Centre for Magnetic Resonance, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark, ⁷Department of Applied Mathematics and Computer Science, Technical University of Denmark, Kongens Lyngby, Denmark

The existence of a ventral fronto-occipital association pathway in non-human primates similar to the inferior fronto-occipital fasciculus (IFOF) in humans, is nowadays still largely debated. In this study, we elucidate the existence, course and terminations of such a pathway using in the same non-human primate (vervet monkey) both ex-vivo diffusion-weighted tractography and blunt microdissection. From a methodological point of view, it allows an unprecedented anatomical validation of advanced tractography with microdissection for the first time in the same specimen.

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