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Abstract #0736

Post-mortem mapping of cortical layers using combined multicompartmental relaxometry and diffusometry at ultra-high field (7T and 11.7T)

Justine Beaujoin1,2,3, Christophe Destrieux4, Fabrice Poupon5, Ilyess ZEMMOURA4, Jean-François Mangin2,3,5,6, and Cyril Poupon1,2,3

1UNIRS, CEA/DRF/Neurospin, Gif-sur-Yvette, France, 2Université Paris-Saclay, Orsay, France, 3FLI / Noeud Paris-Sud, Orsay, France, 4Université François-Rabelais de Tours, INSERM, Imagerie et Cerveau UMR 930, Tours, France, 5UNATI, CEA/DRF/Neurospin, Gif-sur-Yvette, France, 6http://cati-, Gif-sur-Yvette, France

The human cerebral cortex has a laminar structure presenting distinct cell organization and myelination. In this work, we compare the lamination observed from multicompartmental quantitative relaxometry- or diffusometry-based microstructural ultra-high field MRI on a post-mortem human brain visual cortex sample. This study reveals that the quantitative intra-neuritic volume fraction map provides a better delineation of the line of Gennari in the primary visual cortex whereas multicompartment T1 relaxometry provides a better segmentation of the superfical layers. Thus, this study strongly plays in favour of a combination of relaxometry and diffusometry methods to robustly map the cortex lamination in humans.

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