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Abstract #0737

A tunable permeability phantom for validating time-dependent diffusion models

Antonios Papaioannou1, Dmitry Novikov1, and Els Fieremans1

1Center For Biomedical Imaging, New York University Medical Center, New York, NY, United States

Well characterized phantoms are essential for time-dependent diffusion model validations. Here we introduce a phantom made of permeable barriers with highly tunable micro-structural characteristics such as pore size, pore density and permeability and perform time-dependent diffusion measurements using three NMR and MRI systems. Our experimental results agree with the theory of time-dependent diffusion in disordered systems, making the phantom suitable for model validations in clinical and preclinical systems.

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