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Abstract #0738

A new computational framework for complex numerical simulation of diffusion-weighted NMR signal in brain tissue

Marco Palombo1, Daniel C. Alexander1, and Hui Zhang1

1Computer Science Department and Centre for Medical Imaging Computing, University College London, London, United Kingdom

In this work, we introduce a new framework that we developed to use numerical simulations to investigate the complexity of brain tissue at a microscopic level with a detail never realised before. Directly inspired by the advances in computational neuroscience for modelling brain cells, the proposed toolbox enables numerical simulation of molecular diffusion within realistic digitalised brain cells, such as neurons and glia. Here we show a select set of examples offered by this new toolbox to demonstrate its versatility and potentiality. Further development is ongoing, which will support even more realistic conditions and fully digitalised tissues.

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