Abstract #0743

Building a probabilistic atlas of the human corticospinal tract from 410 healthy participants by using enhanced bundle-specific tractography.

Chenot Quentin¹, Nathalie Tzourio-Mazoyer¹, François Rheault², Maxime Descoteaux², and Laurent Petit¹

¹Groupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives (GIN-IMN) - UMR 5293, CNRS, CEA Université de Bordeaux, Bordeaux, France, ²Sherbrooke Connectivity Imaging Lab (SCIL), Université de Sherbrooke, Sherbrooke, QC, Canada

Current limitations of diffusion-weighted tractography algorithms face the complexity of white matter fiber crossings, especially for the cortico-lateral projections of the cortico-spinal tract (CST) in the human brain. In this work, to improve cortico-spinal tracking in crossing areas we combined accurate anatomical region positioning along the CST in each individual with a new bundle-specific tractography algorithm. We thus built a probabilistic atlas of the whole-fanning CST in 410 healthy participants.

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