Abstract #0744

Validation of dentato-rubro-thalamic tract in squirrel monkey brain

Yurui Gao^1,2, Kurt Schilling^1,2, Iwona Stepniewska³, Guozhen Luo^4,5, Bennett Landman^2,6, Hong Yu⁷, Daniel Claassen⁸, Benoit Dawant⁶, and Adam Anderson^1,2

¹Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ²Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³Psychology, Vanderbilt University, Nashville, TN, United States, ⁴Physics and Astronomy, Vanderbilt University, Nashville, TN, United States, ⁵Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, United States, ⁶Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States, ⁷Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United States, ⁸Neurology, Vanderbilt University Medical Center, Nashville, TN, United States

The dentato-rubro-thalamic-tract (DRTT) has recently been suggested as a target for tremor control in deep brain stimulation and stereotactic radiosurgery, however, its efficacy has been challenged because different approaches to diffusion MRI (dMRI) tractography exhibited significantly different sensitivity in detecting the DRTT. We implemented a framework to quantitatively evaluate the performance of dMRI tractography by comparing the dMRI tracts to the histological DRTT identified from Nissl-stained sections in the same squirrel monkey brain. The Jaccard index between our dMRI tractography strategy and the histological DRTT is above 0.7. In the future, other tractography strategies can be tested using this framework.

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