Meeting Banner
Abstract #0744

Validation of dentato-rubro-thalamic tract in squirrel monkey brain

Yurui Gao1,2, Kurt Schilling1,2, Iwona Stepniewska3, Guozhen Luo4,5, Bennett Landman2,6, Hong Yu7, Daniel Claassen8, Benoit Dawant6, and Adam Anderson1,2

1Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, 2Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 3Psychology, Vanderbilt University, Nashville, TN, United States, 4Physics and Astronomy, Vanderbilt University, Nashville, TN, United States, 5Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, United States, 6Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States, 7Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, United States, 8Neurology, Vanderbilt University Medical Center, Nashville, TN, United States

The dentato-rubro-thalamic-tract (DRTT) has recently been suggested as a target for tremor control in deep brain stimulation and stereotactic radiosurgery, however, its efficacy has been challenged because different approaches to diffusion MRI (dMRI) tractography exhibited significantly different sensitivity in detecting the DRTT. We implemented a framework to quantitatively evaluate the performance of dMRI tractography by comparing the dMRI tracts to the histological DRTT identified from Nissl-stained sections in the same squirrel monkey brain. The Jaccard index between our dMRI tractography strategy and the histological DRTT is above 0.7. In the future, other tractography strategies can be tested using this framework.

This abstract and the presentation materials are available to members only; a login is required.

Join Here