Abstract #0751

Reversible white matter restricted diffusion in patients with cerebral malaria via ADC measurement on a 0.35T MR scanner

Yuchuan Zhuang¹, Sarah Mohajeri Moghaddam ², Samuel D Kampondeni ^2,3, Madalina Tivarus ², Gretchen L Birbeck ⁴, Michael J Potchen ², and Jianhui Zhong²

¹Electrical and Computer Engineering, University of Rochester, Rochester, NY, United States, ²Department of Imaging Sciences, University of Rochester, Rochester, NY, United States, ³Malawi MRI Center, Queen Elizabeth Central Hospital, Blantyre, Malawi, ⁴Department of Neurology, University of Rochester, Rochester, NY, United States

White matter abnormalities are commonly identified on cerebral malaria patients. We proposed a method to overcome technical limitations of low-field MRI, and quantitatively calculate the ADC and b0 maps, enabling discrimination of the true restricted diffusion from T2 shine-through. A unique pattern of reversible restricted diffusion was identified in some patients.

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