DTI templates of the adult human brain are commonly used in neuroimaging, and their characteristics influence the accuracy of the application. The purpose of this work was to compare eight available standardized DTI templates to each other, as well as to study-specific templates, in terms of template characteristics and performance in spatial normalization and detection of small inter-group FA differences. The IIT v.3.0 template was shown to combine a number of desirable characteristics, and allows higher inter-subject spatial normalization accuracy and detection of smaller inter-group FA differences, compared to other templates, including study-specific templates, for both younger and older adults.
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