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Abstract #0757

Validation of the VERDICT MRI Framework using a Novel Computational Model of Diffusion and Flow in Real-World Tumours.

Ben Hipwell1, Tom Roberts1, Paul Sweeney2, Morium Ali2, Angela D'Esposito3, Eleftheria Panagiotaki2, Mark Lythgoe2, Daniel Alexander2, Rebecca Shipley2, and Simon Walker-Samuel2

1Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 2University College London, London, United Kingdom, 3University of Bologna, Bologna, Italy

Compartmental models are increasingly being used to quantify diffusion MRI signals from tumours. We have developed a complex, multiscale mathematical modelling platform for simulating tumour pathophysiology, using high-resolution optical imaging data from complete tumour samples. Diffusion MRI signals from these tumours were simulated, including vascular flow and intra- and extracellular diffusion. These data were fitted to the VERDICT compartmental model, and the resulting parameters compared against ground truth simulation values. Cell radius and intra/extracellular fractional volume parameters and respective ground truth values were strongly correlated. A more complex relationship was found in vascular volume fractions.

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