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Abstract #0779

Quantitative 3D Deuterium MRS Imaging of Glucose Metabolisms in the Rat Brain

Ming Lu1, Xiao-Hong Zhu1, Yi Zhang1, and Wei Chen1

1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States

Assessment of metabolic coupling between glycolysis and oxidation is crucial for understanding neuroenergetics. Based on our recently developed in vivo Deuterium (2H) MR (DMR) spectroscopic approach, we further developed a quantitative DMR imaging method for simultaneous measuring the glucose consumption rate (CMRglc) and TCA cycle flux (VTCA) in rat brain at 16.4 T. Regional metabolic rates were quantified and compared between two brain conditions. The metabolite images were also generated. This work demonstrates the feasibility and reliability of in vivo DMR imaging for assessing glucose metabolisms, which makes it possible to image CMRglc and VTCA in brains under different states.

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