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Abstract #0783

Multidimensional T1 Relaxation-T2 Relaxation Correlation Spectroscopic Imaging (RR-CSI) for In Vivo Imaging of Microstructure

Daeun Kim1, Jessica L. Wisnowski2, Christopher T. Nguyen3, and Justin P. Haldar1

1Electrical Engineering, University of Southern California, Los Angeles, CA, United States, 2Radiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, 3Cardiology, Massachusetts General Hospital, Boston, MA, United States

We propose a new multidimensional MRI experiment called T1 Relaxation-T2 Relaxation Correlation Spectroscopic Imaging (RR-CSI) for probing microstructure. RR-CSI acquires imaging data with two-dimensional relaxation contrast encoding and estimates a high-dimensional spectroscopic image by using spatially-constrained reconstruction. The spectroscopic image comprises a full 2D T1-T2 spectrum at every voxel. The distinct peaks in these spectra correspond to different microscopic tissue compartments, which enables spatial mapping of microstructure. Compared to conventional methods, RR-CSI has improved capabilities for resolving tissue microenvironments with similar relaxation parameters. RR-CSI is demonstrated with real MRI data, including the first in vivo human brain results.

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