Abstract #0783

Multidimensional T1 Relaxation-T2 Relaxation Correlation Spectroscopic Imaging (RR-CSI) for In Vivo Imaging of Microstructure

Daeun Kim¹, Jessica L. Wisnowski², Christopher T. Nguyen³, and Justin P. Haldar¹

¹Electrical Engineering, University of Southern California, Los Angeles, CA, United States, ²Radiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, ³Cardiology, Massachusetts General Hospital, Boston, MA, United States

We propose a new multidimensional MRI experiment called T₁ Relaxation-T₂ Relaxation Correlation Spectroscopic Imaging (RR-CSI) for probing microstructure. RR-CSI acquires imaging data with two-dimensional relaxation contrast encoding and estimates a high-dimensional spectroscopic image by using spatially-constrained reconstruction. The spectroscopic image comprises a full 2D T₁-T₂ spectrum at every voxel. The distinct peaks in these spectra correspond to different microscopic tissue compartments, which enables spatial mapping of microstructure. Compared to conventional methods, RR-CSI has improved capabilities for resolving tissue microenvironments with similar relaxation parameters. RR-CSI is demonstrated with real MRI data, including the first in vivo human brain results.

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