Abstract #0784

Comparison of Inhomogeneous Magnetization Transfer and Myelin Water Fraction Ex-Vivo at 7T

Michelle H. Lam^1,2, Andrew Yung², Alan P. Manning¹, Cornelia Laule^1,2,3,4,5, G.R. Wayne Moore^3,4,6, Anastasia Smolina^1,2,7, Irene M. Vavasour^2,5, Erin L. MacMillan^2,8,9, Carl Michal¹, Alex L. Mackay^1,2,5, and Piotr Kozlowski^1,2,3,5

¹Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ²UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ³International Collaboration on Repair Discoveries, Vancouver, BC, Canada, ⁴Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, ⁵Radiology, University of British Columbia, Vancouver, BC, Canada, ⁶Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada, ⁷Physics and Astronomy, McMaster University, Hamilton, ON, Canada, ⁸MR Clinical Science, Phillips Healthcare Canada, Markham, ON, Canada, ⁹ImageTech Lab, Faculty of Applied Sciences, Simon Fraser University, Surrey, BC, Canada

Inhomogeneous magnetization transfer (ihMT) shows promise as a myelin specific MR technique. This specificity is thought to emerge from ihMT’s sensitivity to dipolar relaxation times, which can differ dramatically between lipids (which are the main component of myelin) and other brain constituents. We compared both ihMT and conventional MT to myelin water imaging using ex-vivo normal and multiple sclerosis brain tissue, to determine how the white matter and grey matter signal intensities vary across these three proposed myelin specific techniques.

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