Abstract #0792

Longitudinal assessment of adolescent brain myelination using a pulsed magnetization transfer approach

Erika P Raven^1,2, Peter van Gelderen¹, Diana H Fishbein³, John W VanMeter², and Jeff H Duyn¹

¹Advanced MRI, LFMI, NINDS, NIH, Bethesda, MD, United States, ²Georgetown Center for Functional and Molecular Imaging, Washington, DC, United States, ³Program for Translational Research on Adversity and Neurodevelopment, The Pennsylvania State University, University Park, MD, United States

The spatiotemporal growth trajectories of white matter, and in particular myelin, are an important part of cognitive development during adolescence. Quantitative magnetization transfer (qMT) imaging can be used to measure the fraction of non-water protons (f_MT) as an estimate of myelin in vivo. Here we used a recently developed, time-efficient pulsed MT approach to extract f_MT from white matter regions at different stages of development in a community-based cohort of adolescents. We tested the sensitivity of this approach for detecting region-specific change in f_MT in repeated scans that covered a period of 18 months.

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