In-vivo quantitative MRI (qMRI) aims at characterizing the biological properties of brain tissue. However, qMRI parameters are sensitive both to the molecular tissue properties and to the water content within each voxel. We introduce a novel approach that disentangles these two contributions to qMRI parameters and provides tissue-specific measurements. This is achieved by evaluating the dependency of qMRI parameters on the non-water fraction. Using phantoms, we show that this dependency changes as a function of molecular composition. In the human brain, our method reveals unique tissue signatures for different brain regions, along with region-specific age-related changes.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords