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Abstract #0796

Absolute Cerebral Blood Flow Derived from Low GBCA Dose DCE-MRI in Patients with  Type 2 Neurofibromatosis

Ka-Loh Li1, Daniel Lewis1,2, Xiaoping Zhu1, and Alan Jackson1

1Division of Informatics, Imaging and Data Science, University of Manchester, Manchester, United Kingdom, 2Department of Neurosurgery, Salford Royal NHS Foundation Trust, Manchester, United Kingdom

A newly developed low dose T1W-DCE-MRI method, ACcomb, was used to estimate the absolute CBF of vestibular schwannomas (VS) and normal appearing brain tissue in a group of 12 consecutive type 2 neurofibromatosis (NF2) patients, undergoing anti-angiogenic bevacizumab treatment. This new method consistently displayed excellent gray-white matter flow contrast and produced mean GM and WM CBF estimates consistent with previous literature values. Use of this new method showed that at 90 days post bevacizumab treatment, there was increased positive correlation between CBF and estimated plasma volume within the VS, and a significant increase in CBF within normal appearing white matter.

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