Abstract #0797

Comparison of the Tofts and the Shutter Speed Model for DCE-MRI in patients with Brain Glioma

Marianna Inglese^1,2, Lesley Honeyfield³, Eric Aboagye¹, Adam D Waldman^4,5, and Matthew Grech-Sollars^1,3

¹Department of Surgery and Cancer, Imperial College London, London, United Kingdom, ²Department of Computer, Control and Management Engineering Antonio Ruberti, La Sapienza University of Rome, Rome, Italy, ³Department of Imaging, Imperial College Healthcare NHS Trust, London, United Kingdom, ⁴Department of Medicine, Imperial College London, London, United Kingdom, ⁵Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom

DCE-MRI allows interrogation of patho-physiological insular micro-environments through the passage of contrast agents and model-based pharmacokinetic analysis. In this study, we analysed data from 14 patients with suspected primary glioma who underwent DCE-MRI. Using both the Tofts model and the shutter speed model (SSM), we evaluated the performance and variability of each extracted parameter. We then analysed the ability of the two models to discriminate between tumour and healthy tissue to test the differences between the two methods. Results showed higher performance for the SSM, with a high robustness for the mean capillary water molecule lifetime τ_i.

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