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Abstract #0799

Consensus acquisition protocol for quantitative MRI of the cervical spinal cord at 3T

Stephanie Alley1, Guillaume Gilbert2, Claudia A.M. Gandini Wheeler-Kingshott3,4,5, Rebecca S. Samson3, Francesco Grussu3,6, Allan Martin7, Elise Bannier8,9, Virginie Callot10, Seth A. Smith11, Junqian Xu12, Blake Dewey13, Kenneth A. Weber II14, Todd Parrish15, Donald McLaren16, Gareth J. Barker17, Nico Papinutto18, Maryam Seif19,20, Patrick Freund20,21,22, Robert L. Barry23, Samantha By2, Sridar Narayanan24, and Julien Cohen-Adad1,25

1NeuroPoly Lab, Polytechnique Montreal, Montreal, QC, Canada, 2MR Clinical Science, Philips Healthcare, Gainesville, FL, United States, 3Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 4Brain MRI 3T Research Centre, C. Mondino National Neurological Institute, Pavia, Italy, 5Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 6Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, 7Department of Surgery, University of Toronto, Toronto, ON, Canada, 8VisAGeS team, INRIA (INSERM, CNRS, Rennes 1 University), Rennes, France, 9Department of Radiology, Rennes University Hospital, Rennes, France, 10Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR 7339, CNRS Aix-Marseille Université, Marseille, France, 11Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, 12Translational and Molecular Imaging Institute, Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 13Department of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD, United States, 14Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, United States, 15Department of Radiology, Northwestern Feinberg School of Medicine, Chicago, IL, United States, 16Biospective, Inc., Montreal, QC, Canada, 17Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom, 18Department of Neurology, University of California San Francisco, San Francisco, CA, United States, 19Department of Neurophysics, Max Planck Institute, Leipzig, Germany, 20Spinal Cord Injury Center Balgrist, Balgrist University Hospital, Zurich, Switzerland, 21Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom, 22Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, London, United Kingdom, 23Harvard-MGH Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 24Montreal Neurological Institute, McGill University, Montreal, QC, Canada, 25Functional Neuroimaging Unit, CRIUGM, University of Montreal, Montreal, QC, Canada

We present a consensus recommendation for best practices in high quality data acquisition of quantitative MRI (qMRI) of the cervical spinal cord at 3T. We propose protocols for computing cross-sectional area (CSA), magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI) from three main vendors. We demonstrate these protocols by repeated scans of a single subject, from which the data and analysis scripts are made available. We hope harmonized and publicly-available spinal cord imaging protocols will promote reproducibility and thus accelerate the progress for spinal cord measurements to be more widely accepted as MRI biomarkers in multicenter studies.

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