The interest in white matter hyperintensities (WMHs) has increased recently as they have been associated with various clinical disorders such as stroke and dementia. Although postmortem histopathological studies reported various underlying pathophysiological mechanisms, in vivo studies have not been specific enough to conform those results. We attempted to fill this gap with quantitative MRI of water content, T1, T2*, and MT parameters. These parameters were analyzed for white and grey matter globally and for manually segmented WMHs. Based on the changes identified for WMHs and their trend with WMH load, we were able to complement histopathological findings.