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Abstract #0800

Quantitative Magnetic Resonance Imaging of the Human Brain with White Matter Hyperintensities: a New Approach towards Understanding the Underlying Pathology

Elene Iordanishvili1, Melissa Schall1, Ricardo Loucao1, Svenja Caspers2, Ketevan Kotetishvili3, Jon Shah1,4, and Ana-Maria Oros-Peusquens1

1Institute of Neuroscience and Medicine - 4 (INM-4), Research Centre Juelich, Juelich, Germany, 2Institute of Neuroscience and Medicine - 1 (INM-1), Research Centre Juelich, Juelich, Germany, 3Georgian Technical University (GTU), Tbilisi, Georgia, 4J├╝lich Aachen Research Alliance (JARA), Juelich, Germany

The interest in white matter hyperintensities (WMHs) has increased recently as they have been associated with various clinical disorders such as stroke and dementia. Although postmortem histopathological studies reported various underlying pathophysiological mechanisms, in vivo studies have not been specific enough to conform those results. We attempted to fill this gap with quantitative MRI of water content, T1, T2*, and MT parameters. These parameters were analyzed for white and grey matter globally and for manually segmented WMHs. Based on the changes identified for WMHs and their trend with WMH load, we were able to complement histopathological findings.

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