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Abstract #0808

Amide chemical exchange saturation transfer at 7T: A possible biomarker for detecting early response to neoadjuvant chemotherapy in breast cancer patients

Erwin Krikken1, Vitaliy Khlebnikov1, Moritz Zaiss2, Rajni Aarti Jibodh3, Paul J van Diest4, Peter R Luijten1, Dennis W.J. Klomp1, Hanneke W.M. van Laarhoven3, and Jannie P Wijnen1

1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 3Medical Oncology, Academic Medical Centre Amsterdam, Amsterdam, Netherlands, 4Pathology, UMC Utrecht, Utrecht, Netherlands

Neoadjuvant chemotherapy (NAC) has an important role in the treatment of breast cancer and the need for early detection of treatment response is high. Therefore we investigated the feasibility of using APT CEST at 7T as a biomarker for this purpose. Ten lesions were included and APT signal before and after the first cycle of NAC were correlated to the pathological response. Significant differences were found in APT signal corresponding with the pathological response. These results suggest that APT CEST may be used to predict the response to NAC treatment in an early stage.

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