Abstract #0807

Hyperpolarized-13C Imaging of Treatment Responses on Prostate Cancer Patients using 3D Dynamic CS-EPSI Techniques

Hsin-Yu Chen¹, Peder E.Z. Larson¹, Jeremy W. Gordon¹, Robert A. Bok¹, Marcus Ferrone², Mark van Criekinge¹, Lucas Carvajal¹, Natalie Korn¹, Rahul Aggarwal³, Pamela N. Munster³, Sarah J. Nelson¹, John Kurhanewicz¹, and Daniel B. Vigneron¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA, United States, ³School of Medicine, University of California, San Francisco, San Francisco, CA, United States

Two unmet clinical needs facing the management of prostate cancer are to determine the best treatment for individual patients and to evaluate therapy response. In this study, we applied 3D dynamic imaging technique using hyperpolarized ¹³C nuclei to non-invasively probe prostate cancer metabolism. Pyruvate-to-lactate conversion k_PL correlated well with biopsy and histological finding in pre-surgery prostate cancer patients. k_PL values dramatically decreased in a patient 6 weeks into androgen-deprivation therapy with associated PSA decrease, indicating early treatment response. A non-responder patient with castration-resistant cancer exhibited high k_PL one month after treatment that correlated with clinical progression.

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