Abstract #0812

Evaluating Therapeutic Response of Glioblastoma (GBM) with Chemical Exchange Saturation Transfer (CEST)

Hatef Mehrabian^1,2, Sten Myrehaug³, Hany Soliman³, Arjun Sahgal³, and Greg J Stanisz¹

¹Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ²Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ³Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Early assessment of glioblastoma (GBM) response to standard 6-week chemo-radiation enables changing or adjusting therapy in patients with progressive tumors. Chemical Exchange Saturation Transfer (CEST) probes the concentration and exchange of labile proteins and peptides in ht tumor and is more sensitive to treatment-induced effects. CEST was capable of differentiating progressors from non-progressors as early as two weeks into the treatment. Moreover, certain CEST metrics (i.e. MTR_NOE, MTR_Amide, CEST_NOE) were capable of characterizing GBM aggressiveness even before the start of the treatment.

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