We describe measurement of work dependence of exercise response of diffusion contrast in calf muscle with a multiple echo diffusion tensor imaging (MEDITI) in a clinical 3 T scanner. With radial imaging, accelerated diffusion encoding, and compressed sensing reconstruction, spatial resolution of 3.7 mm and temporal resolution of 16 s was achieved. Using an MR-compatible ergometer with pneumatic resistance and force/displacement monitoring, post-exercise recovery of T2 and DTI metrics following plantarflexion in gastrocnemius muscle were monitored as a function of total normalized work. Exercise response showed significant anisotropy, and trends of higher response with work were observed.
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