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Abstract #0821

Both oxygen supply and phosphocreatine recovery rate show proximo-distal gradients along the human tibialis anterior after exercise

Linda Heskamp1, Franciska Lebbink1, Mark Jacobus van Uden1, Marnix Christiaan Maas1, Jurgen Claassen2, Andreas Boss1, and Arend Heerschap1

1Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, 2Geriatrics, Radboud university medical center, Nijmegen, Netherlands

Since the rate of phosphocreatine recovery after exercise varied substantially within the tibialis anterior, we wondered if O2 supply also varied along this muscle. Therefore, we applied near infra-red spectroscopy to study the dynamic equilibrium of O2 supply and O2 utilization, intravoxel incoherent motion imaging for muscle perfusion and 31P-MRS during and after isometric exercise of the tibialis anterior. We observed higher post-exercise perfusion and faster phosphocreatine and oxyhemoglobin recovery proximally than distally in the tibialis anterior, indicating a proximo-distal gradient in O2 supply. This may be an adaptation to a higher proximal energy requirement.

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