Since the rate of phosphocreatine recovery after exercise varied substantially within the tibialis anterior, we wondered if O2 supply also varied along this muscle. Therefore, we applied near infra-red spectroscopy to study the dynamic equilibrium of O2 supply and O2 utilization, intravoxel incoherent motion imaging for muscle perfusion and 31P-MRS during and after isometric exercise of the tibialis anterior. We observed higher post-exercise perfusion and faster phosphocreatine and oxyhemoglobin recovery proximally than distally in the tibialis anterior, indicating a proximo-distal gradient in O2 supply. This may be an adaptation to a higher proximal energy requirement.
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