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Abstract #0820

Magnetic resonance measurements of fat content and water diffusion in muscles of glucocorticoid-treated patients with polymyalgia rheumatica compared with healthy volunteers.

John D Biglands1, Steven F Tanner1, Ai Lyn Tan1,2, Sarah L Mackie1,2, Elizabeth M A Hensor1,2, John P Ridgway1, Paul Emery1,2, Thorsten Feiweier3, Emma Harris4, Paul M Stewart5, and Andrew Grainger1

1NIHR Musculoskeletal Biomedical Research Centre, Leeds, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, Leeds, United Kingdom, 3Siemens Healthcare GmbH, Erlangen, Germany, 4School of Human and Health Science, University of Huddersfield, Huddersfield, United Kingdom, 5School of Medicine, University of Leeds, Leeds, United Kingdom

The purpose of this study was to assess differences in fat fraction and water diffusion between muscles in the healthy thigh and to assess differences between glucocorticoid treated patients with polymyalgia rheumatic (PMR) and healthy controls. Twenty five healthy volunteers and sixteen patients with PMR undergoing glucocorticoid treatment underwent MRI to assess muscle fat fraction and diffusion. The study found that the hamstrings have greater fat fraction and reduced diffusion compared to quadriceps in healthy individuals. Furthermore, alterations in fat fraction and diffusion parameters associated with glucocorticoid-treated PMR are more readily detectable in the hamstrings than the quadriceps.

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