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Abstract #0844

Caffeine and brain development in preterm children

Claire Kelly1,2, Wenn Lynn Ooi1,2, Joseph Yuan-Mou Yang2,3,4, Jian Chen2,5, Chris Adamson2, Katherine Lee6,7, Jeanie Cheong1,8,9, Peter Anderson1,7,10, Lex Doyle1,7,8,9, and Deanne Thompson1,2,7,11

1Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia, 2Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, 3Department of Neurosurgery, The Royal Children's Hospital, Melbourne, Australia, 4Neuroscience research, Murdoch Children's Research Institute, Melbourne, Australia, 5Department of Medicine, Monash Medical Centre, Monash University, Melbourne, Australia, 6Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia, 7Department of Paediatrics, The University of Melbourne, Melbourne, Australia, 8Newborn research, The Royal Women's Hospital, Melbourne, Australia, 9Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, 10Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Australia, 11Florey Institute of Neuroscience and Mental Health, Melbourne, Australia

We investigated effects of neonatal caffeine treatment on brain structure and longitudinal development in a subset of preterm children from a randomized, placebo-controlled trial. Children had MRI at age 11 years (n=118; 64 received caffeine, 54 received placebo), of whom 43 (21 caffeine, 22 placebo) had MRI at term-equivalent age. Global and regional brain volumes, cortical morphometry and white matter microstructure were similar between treatment groups at age 11 years, as was brain development from term-equivalent age to 11 years of age. Any benefits of caffeine on brain structure weaken over time and were not apparent at age 11 years.

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