Abstract #0844

Caffeine and brain development in preterm children

Claire Kelly^1,2, Wenn Lynn Ooi^1,2, Joseph Yuan-Mou Yang^2,3,4, Jian Chen^2,5, Chris Adamson², Katherine Lee^6,7, Jeanie Cheong^1,8,9, Peter Anderson^1,7,10, Lex Doyle^1,7,8,9, and Deanne Thompson^1,2,7,11

¹Victorian Infant Brain Studies, Murdoch Children's Research Institute, Melbourne, Australia, ²Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, ³Department of Neurosurgery, The Royal Children's Hospital, Melbourne, Australia, ⁴Neuroscience research, Murdoch Children's Research Institute, Melbourne, Australia, ⁵Department of Medicine, Monash Medical Centre, Monash University, Melbourne, Australia, ⁶Clinical Epidemiology and Biostatistics Unit, Murdoch Children's Research Institute, Melbourne, Australia, ⁷Department of Paediatrics, The University of Melbourne, Melbourne, Australia, ⁸Newborn research, The Royal Women's Hospital, Melbourne, Australia, ⁹Department of Obstetrics and Gynaecology, The University of Melbourne, Melbourne, Australia, ¹⁰Monash Institute of Cognitive and Clinical Neurosciences, Monash University, Melbourne, Australia, ¹¹Florey Institute of Neuroscience and Mental Health, Melbourne, Australia

We investigated effects of neonatal caffeine treatment on brain structure and longitudinal development in a subset of preterm children from a randomized, placebo-controlled trial. Children had MRI at age 11 years (n=118; 64 received caffeine, 54 received placebo), of whom 43 (21 caffeine, 22 placebo) had MRI at term-equivalent age. Global and regional brain volumes, cortical morphometry and white matter microstructure were similar between treatment groups at age 11 years, as was brain development from term-equivalent age to 11 years of age. Any benefits of caffeine on brain structure weaken over time and were not apparent at age 11 years.

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