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Abstract #0845

Early postnatal music intervention in preterm birth reorganizes salience network interactions

Djalel-Eddine Meskaldji1,2, Lara Lordier1,3, Frédéric Grouiller4, Marie P. Pittet1, Lana Vasung1, François Lazeyras5, Didier Grandjean3, Dimitri Van De Ville5,6, and Petra S Hüppi1

1Division of Development and Growth, Department of Pediatrics, University of Geneva, Geneva, Switzerland, 2Institute of mathematics, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 3Neuroscience of Emotion and Affective Dynamics Lab, Department of psychology and educational sciences, University of Geneva, Geneva, Switzerland, 44 Swiss center for affective neurosciences, University of Geneva, Geneva, Switzerland, 5Department of Radiology and Medical Informatics, University of Geneva, Geneva, Switzerland, 6Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

The aim of this study is to characterize the preterm brain functional connectivity and to test the effectiveness of an early postnatal music intervention on preterm newborn’s functional brain development. We explored functional connectivity by resting state fMRI in 16 full-term 1 to 4 days old newborns and 29 preterm infants (born < 32weeks) at term equivalent age (TEA) randomly assigned to either music intervention (14 newborns) or control group. We identified a network of interest that represents resting state functional connectivity decrease in preterm control compared to full-term newborns. We found salience network functional connectivity to be especially altered by a premature birth but music intervention significantly increased its connectivity. To the best of our knowledge, this study is the first one to observe music effects on brain development in the preterm newborns.

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