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Abstract #0851

Thalamic Lac/NAA threshold of 0.39 on proton MRS predicts outcome following therapeutic hypothermia in neonatal hypoxic ischemic encephalopathy

Subhabrata Mitra1, Giles Kendal1, Cristina Uria-Avellanal1, Alan Bainbridge1, Magdalena Sokolska1, David Price1, Xavier Golay2, and Nikki Robertson1

1University College Hospital, London, United Kingdom, 2University College London, London, United Kingdom

Perinatal hypoxic ischemic brain injury remains a significant cause of neonatal morbidity and mortality. Accurate prediction of neurodevelopmental outcome following HIE is important for parental counselling and directing care towards optimised treatments. Proton MRS derived thalamic Lactate/N-acetylaspartate (Lac/NAA) peak area ratio at 1.5T was a robust MR outcome biomarker in the pre-cooling era; a cut off Lac/NAA of 0.29 accurately predicted outcome. The aim of this work is to identify the cut off threshold of thalamic Lac/NAA at 3T in the cooling era for outcome prediction.

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